SOLUBILITY ENHANCEMENT OF POORLY WATER SOLUBLE DRUGS
نویسندگان
چکیده
منابع مشابه
Solubility Enhancement of Poorly Water Soluble Drugs: a Review
Among all newly discovered chemical entities about 40% drugs are lipophillic and fail to reach market due to their poor water solubility. Drug with poor water solubility cause slow dissolution rates, generally show erratic and incomplete absorption leading to low bioavailability when administered orally. Aqueous solubility of any therapeutically active substance is a key property, as it governs...
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Solid dispersions have been employed to enhance the dissolution rates of poorly water-soluble drugs. Many approaches have been investigated for the preparation of solid dispersions. This paper reports the various solubility enhancement strategies in solid dispersion. The approaches described are fusion (melting), solvent evaporation, lyophilization (freeze drying), melt agglomeration process, e...
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Celecoxib, a diaryl substituted pyrazole, is practically insoluble in water which precludes its use in parenteral and liquid dosage forms. This study explores the solubility enhancement of celecoxib using hydrotropy and cosolvency solubilization approaches. The equilibrium solubility studies were performed using hydrotropes piperazine, sodium citrate, and urea and cosolvents PEG 200, PEG 400, P...
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Enhancement of solubility is one of the difficult tasks which become challenges in formulation development of orally administered drug with poor aqueous solubility. Poor water solubility of drugs often causes significant problems in producing formulations of sufficiently high bioavailability, preventing effective use of the drugs. 'Mixed-solvency ' concept is the phenomenon to increase the solu...
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It is generally recognized that poor solubility is one of the most frequently encountered difficulties in the field of pharmaceutics. Low solubility and subsequent unsatisfactory dissolution rate often compromise oral bioavailability. There are most therapeutic agents used to produce systemic effects by oral route that are the preferred way of administration owing to its several advantages and ...
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ژورنال
عنوان ژورنال: INDONESIAN JOURNAL OF PHARMACY
سال: 2014
ISSN: 2338-9486,2338-9427
DOI: 10.14499/indonesianjpharm25iss1pp1